
Description of item 

Loxoprofen tablet "Kunihiro" is an antipyretic analgesic effective for headache and menstrual pain. Pain and heat are caused by the body's production of a substance called prostaglandins. Loxoprofen tablets "Kunihiro" is a tablet containing loxoprofen sodium hydrate, which suppresses the production of prostaglandins and has an effect on pain and heat.


Ingredient/quantity
In one dose (1 tablet)
・Loxoprofen sodium hydrate
68.1 mg (60 mg as anhydrous)
Lactose hydrate, cellulose, povidone, partially pregelatinized starch, crospovidone, silicic acid anhydride, magnesium stearate, iron sesquioxide are included as additives.

Precautions related to ingredients and amounts
Red spots may appear on the tablet surface due to the pigment used.

Usage/Dose
When symptoms occur, take the next dose with water or hot water without hunger as much as possible.
・Adult (15 years old or older) 1 tablet per dose up to 2 times a day
However, if symptoms appear again, a third dose can be taken. (The interval between doses should be at least 4 hours.)
・Children under 15 years old should not take

Precautions related to usage and dose
(1) Please strictly observe the usage and dose.
(2) How to take out tablets
Press the convex part of the PTP sheet containing the tablet firmly with your fingertips to break the aluminum foil on the back side, take it out and drink. (If accidentally swallowed as it is, it may lead to an unexpected accident such as piercing the mucous membrane of the esophagus.)


Precautions
● Do not do
(If not protected, current symptoms will worsen and side effects will likely occur)
1. Do not take the following people.
(1) People who have had allergic reactions due to this drug or the ingredients of this drug.
(2) People who have had asthma after taking this drug or other antipyretic analgesics or cold remedies.
(3) Children under 15 years.
(4) Person who receives the next treatment in medical institution.
Gastric/duodenal ulcer, liver disease, kidney disease, heart disease
(5)Patients who have been pointed out by a doctor to have blood abnormalities (blood diseases) such as low red blood cell count (anemia), low platelet count (blood is hard to stop, blood is easy to produce), low white blood cell count, etc.
(6) Pregnant women within 12 weeks of expected delivery date.
2. Do not take any of the following medicines while taking this drug.
Other antipyretic analgesics, colds, sedatives
3. Please do not drink before and after taking.
4. Please do not take it continuously for a long time. (If you continue to experience pain or other symptoms after taking the drug for 3-5 days, discontinue use and consult a doctor.)

● To consult
1. The following people, please consult your doctor, dentist or pharmacist before taking.
(1) Those who are being treated by a doctor or dentist.
(2) Pregnant woman or person who seems to be pregnant.
(3) Breastfeeding person.
(4) Elderly people.
(5) People who have had allergic reactions due to drugs.
(6) Person who received the next diagnosis.
Bronchial asthma, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, mixed connective tissue disease
(7) Those who have had the following illness.
Gastric/duodenal ulcer, liver disease, kidney disease, blood disease
2. If any of the following symptoms appear after using the drug, it may have side effects, so discontinue use immediately and consult your doctor or pharmacist with this package insert.
(1) If symptoms such as excessive hypothermia, collapse (less strength), limb cooling (cold limbs) occur after taking an antipyretic analgesic such as this drug
(2) If peptic ulcer or swelling appears after taking
In rare cases, gastrointestinal bleeding (vomiting blood, nausea/vomiting, abdominal pain, black tar-like stool, bloody stool, etc.), gastrointestinal perforation (having a hole in the gastrointestinal tract, nausea/vomiting, severe abdominal pain, etc.) Serious symptoms such as stenosis/occlusion of small intestine/large intestine (nausea/vomiting, abdominal pain, bloating etc. may occur) may occur. In that case, please see a doctor immediately.
(3) If the following symptoms appear after taking
Related parts
Symptom
Skin
Rash/redness, itch
Digestive organ
Abdominal pain, stomach discomfort, loss of appetite, nausea/vomiting, bloating, heartburn, stomatitis, indigestion
Cardiovascular
Increased blood pressure, palpitation
Neuropsychiatric system
Drowsiness, numbness, dizziness, headache

Other
Chest pain, malaise, hot flashes on the face, fever, anemia, hematuria
In rare cases, the following serious symptoms may occur. In that case, please see a doctor immediately.
Name of symptom
Symptom
Shock (anaphylaxis)
Immediately after administration, itching of the skin, hives, blurring of voice, sneezing, itching of the throat, suffocation, palpitation, opacity of consciousness and the like appear.
Blood disorders
Sore throat, fever, general fatigue, whiteness on face and eyelids, easy bleeding (bleeding gums, nosebleeds, etc.), bruise (color does not disappear even when pressed) etc. appear.
Mucocutaneous eye syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis
High fever, redness of the eyes, sore lips, sore throat, widespread rash/redness of the skin may persist or may worsen rapidly.
Renal impairment
Fever, rash, decreased urine output, swelling of the whole body, general swelling, joint pain (pain in nodes), diarrhea, etc. may occur.
Congestive heart failure
General fatigue, palpitation, shortness of breath, chest discomfort, chest pain, dizziness, fainting, etc. may occur.
Interstitial pneumonia
If you go up the stairs or try to overdo it, you may experience shortness of breath, breathlessness, emptiness, fever, etc., which may suddenly appear or persist.
Liver dysfunction
Fever, itching, rash, jaundice (yellowing of the skin and white of the eyes), brown urine, general malaise, loss of appetite, etc. may occur.
Rhabdomyolysis
Muscles such as limbs, shoulders and hips may be damaged, limbs may become numb, weakness, stiffness, sluggish body, reddish brown urine, etc. may appear.
Aseptic meningitis
Symptoms such as severe headache accompanied by a tight neck, fever, nausea and vomiting. (Such symptoms are most commonly reported in people who are being treated for systemic lupus erythematosus or mixed connective tissue disease)
Asthma
When you take a breath, you may feel squealing, humming, or suffocating.
3. The following symptoms may appear after taking this drug. If you continue or enhance such symptoms, discontinue use and consult your doctor or pharmacist with this package insert. ..
Dry mouth, constipation, diarrhea
4.1-2 If symptoms do not improve after taking 2 times (possibly due to other diseases), discontinue use and consult your doctor, dentist or pharmacist with this package insert.


Precautions for storage and handling
(1) Store in a cool, dry place out of direct sunlight.
(2) Please keep out of reach of children.
(3) To avoid misuse, please keep it in another container to maintain its quality.
(4) Please do not take the product after the expiration date.


Contact Us 
Houkando Pharmaceutical Co.
Customer consultation desk
Toll free number 0120-023520
Reception hours Weekdays 9:00 to 17:00 (excluding Saturdays, Sundays and holidays)
Contact information for side effect damage relief system
(Germany) Pharmaceuticals and Medical Devices Agency
Telephone 0120-149-931 (toll free)


